In recent years chronic inflammation has been identified as a contributor to multiple diseases.
Meta-analysis(study of multiple studies) of research findings is showing Coenzyme Q10 as having a positive impact on reducing inflammation.
A recent search of PubMed showed solid interest in meta analysis of CoQ10 efficacy in reducing inflammation.
In a review of the abstracts for these studies a few items of note emerge:
- Chronic inflammation as a contributor to the onset of metabolic diseases appears to be widely accepted.
- CoQ10 is consistently described as potentially having an effect on inflammation .
- Studies focus in on recognized inflammatory factors such as –
- interleukin-6 – IL-6
- tumor necrosis factor-alpha – TNF-a
- C reactive protein – CRP
- Studies cite caution in interpreting results due to variances in underlying studies data(i.e. lack of homogeneity, sample sizes )
Generally the studies were supportive of the positive impact CoQ10 has on chronic inflammation. None cited an adverse effect.
Sample conclusions from recent meta analyses.
CoQ10 supplementation may partly improve the process of inflammatory
state. The effects of CoQ10 on inflammation should be further investigated by conducting larger sample size…
In conclusion, this meta-analysis of RCTs suggests significant lowering effects of CoQ10 on CRP, IL-6 and TNF-α. However, results should be
interpreted with caution because of the evidence of heterogeneity and limited number of studies…
In conclusion, this meta-analysis of RCTs suggests significant lowering effects of CoQ10 on CRP, IL-6 and TNF-α. However, results should be interpreted with caution because of the evidence of heterogeneity
In conclusion, CQ10 supplementation has a borderline favourable effect on CRP levels, and a significant effect on IL-6 level. This suggests that CQ10 supplementation likely attenuates subclinical inflammation.
A number of conclusions are similar to these above. RCTs reference Random Controlled Trials.
Find more through a search at PubMed.