Melatonin – Cancer Fighter

Published in cancer

Melatonin: A Promising Ally in the Fight Against Cancer?

Melatonin, long known as the sleep hormone, has emerged as a potential player in the battle against cancer. While not a cure itself, research suggests melatonin possesses properties that could be beneficial when used alongside conventional cancer therapies. This essay will explore the potential anti-cancer effects of melatonin, drawing on evidence from PubMed-indexed studies.

One promising area of research focuses on melatonin’s ability to suppress cancer cell growth. Studies have shown that melatonin can inhibit the proliferation of various cancer cells, including those associated with breast, prostate, and endometrial cancers [2]. This effect appears to be mediated by melatonin’s influence on cellular processes like DNA methylation, a mechanism that regulates gene expression [1]. Melatonin may also enhance the effectiveness of traditional cancer treatments. Research suggests it can act synergistically with chemotherapy and radiation, potentially improving their efficacy while reducing side effects [3].

Melatonin’s antioxidant properties are another potential weapon in the fight against cancer. Cancer cells often exhibit high levels of reactive oxygen species (ROS), molecules that damage healthy cells and contribute to tumor growth. Melatonin’s antioxidant capabilities may help neutralize these harmful ROS, offering some protection against cancer development [2].

However, it’s important to acknowledge that the research on melatonin and cancer is still evolving. While pre-clinical studies offer promising results, clinical trials haven’t yet established a definitive role for melatonin in cancer treatment. Some studies haven’t shown a clear benefit in terms of survival or tumor shrinkage [4]. Additionally, the optimal dosage and long-term safety of melatonin supplementation in cancer patients require further investigation.


Melatonin’s potential anti-cancer properties are a subject of ongoing research with encouraging pre-clinical data. Its ability to inhibit cancer cell growth, enhance traditional therapies, and neutralize ROS suggests a possible role as an adjuvant therapy. However, more clinical trials are needed to determine the true efficacy and safety of melatonin in cancer management. It’s crucial for cancer patients to consult with their doctors before taking any supplements, including melatonin, to ensure they don’t interfere with their current treatment plan.